1. Radiation sterilization method

This legal system refers to the placement of sterilized items under suitable radiation sources γ The method of killing microorganisms by ionizing radiation in an electron beam generated by radiation or a suitable electron accelerator. The most commonly used 60Co in this method- γ Radiation sterilization. Medical devices, containers, production aids, raw materials and finished products that are not damaged by radiation can all be sterilized using this method.

2. Dry heat sterilization method

This law refers to the method of placing items in equipment such as dry heat sterilization cabinets and tunnel sterilizers, and using dry hot air to kill microorganisms or eliminate pyrogenic substances. This method is suitable for sterilization of items that are resistant to high temperatures but not suitable for use with damp heat sterilization, such as glassware, metal containers, fiber products, solid test drugs, liquid paraffin, etc.

3. Ethylene oxide sterilization method

Ethylene oxide, also known as ethylene oxide, is a colorless liquid with an aromatic ether odor at low temperatures. Its boiling point is 10.8 ℃, its olfactory threshold is 760 mg/m~1064 mg/m, and its density is 1.52; Ethylene oxide is flammable and explosive, with a minimum combustion concentration of 3%. Ethylene oxide has strong gas penetration.

4 Ozone sterilization method

Ozone is a strong oxidant and the sterilization process belongs to a biochemical oxidation reaction. Ozone can oxidize the enzymes needed to break down glucose inside bacteria, causing them to inactivate and die. Directly interacting with bacteria and viruses, destroying their organelles, DNA, and RNA, disrupting their metabolism and leading to bacterial death.

The nature and expected use of medical devices to a certain extent determine the sterilization method adopted for sterile packaging, and different sterilization methods also affect the use of packaging system materials. For example, high adsorption items are not suitable for ethylene oxide sterilization (such as gauze, cotton products, wood products, etc.); Medical devices containing PE components are not resistant to high temperatures and are not suitable for high-pressure steam sterilization; Expensive instruments may choose sterilization methods with short sterilization cycles to increase usage frequency, etc.

The nature of medical devices also determines to some extent the sterile packaging system that should be adopted. For example, items that require penetration to achieve sterilization should be packaged in sterile packaging with good breathability; Medical devices used immediately after sterilization, such as those sterilized in a sterile room, can be packaged naked.